Cell populations involved in the processes of local mucosal defense in extended partially edentulous and completely edentulous patients. Clinical and immunohistochemical study.
Identifieur interne : 001354 ( Main/Exploration ); précédent : 001353; suivant : 001355Cell populations involved in the processes of local mucosal defense in extended partially edentulous and completely edentulous patients. Clinical and immunohistochemical study.
Auteurs : Monica Mihaela Cr I Oiu [Oman] ; Claudiu M Rg Ritescu ; Alma Florescu ; Roxana Pascu ; Alina Monica Pico ; Andrei Pico ; Mariana Sab U ; Vasile NicolaeSource :
- Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie [ 1220-0522 ] ; 2015.
Descripteurs français
- KwdFr :
- Adulte d'âge moyen, Antigènes CD (métabolisme), Antigènes CD20 (métabolisme), Antigènes de différenciation des myélomonocytes (métabolisme), Bouche édentée (anatomopathologie), Bouche édentée (immunologie), Femelle, Humains, Immunohistochimie, Inflammation, Macrophages (métabolisme), Muqueuse de la bouche (anatomopathologie), Muqueuse de la bouche (immunologie), Mâle, Plasmocytes (métabolisme), Régulation de l'expression des gènes, Sujet âgé, Épithélium (anatomopathologie).
- MESH :
- anatomopathologie : Bouche édentée, Muqueuse de la bouche, Épithélium.
- immunologie : Bouche édentée, Muqueuse de la bouche.
- métabolisme : Antigènes CD, Antigènes CD20, Antigènes de différenciation des myélomonocytes, Macrophages, Plasmocytes.
- Adulte d'âge moyen, Femelle, Humains, Immunohistochimie, Inflammation, Mâle, Régulation de l'expression des gènes, Sujet âgé.
English descriptors
- KwdEn :
- Aged, Antigens, CD (metabolism), Antigens, CD20 (metabolism), Antigens, Differentiation, Myelomonocytic (metabolism), CD3 Complex (metabolism), CD8 Antigens (metabolism), Epithelium (pathology), Female, Gene Expression Regulation, Humans, Immunohistochemistry, Inflammation, Macrophages (metabolism), Male, Middle Aged, Mouth Mucosa (immunology), Mouth Mucosa (pathology), Mouth, Edentulous (immunology), Mouth, Edentulous (pathology), Plasma Cells (metabolism).
- MESH :
- chemical , metabolism : Antigens, CD, Antigens, CD20, Antigens, Differentiation, Myelomonocytic, CD3 Complex, CD8 Antigens.
- immunology : Mouth Mucosa, Mouth, Edentulous.
- metabolism : Macrophages, Plasma Cells.
- pathology : Epithelium, Mouth Mucosa, Mouth, Edentulous.
- Aged, Female, Gene Expression Regulation, Humans, Immunohistochemistry, Inflammation, Male, Middle Aged.
Abstract
Considering the fact that extended partial edentation and complete edentation have high incidence rates worldwide, the necessity for correct prosthetic treatment is very important. We performed a clinical study on 37 extended partially edentulous patients and completely edentulous patients, who were divided into three groups. We also performed a morphological study using classic techniques of histology and immunohistochemistry methods on sections obtained from oral mucosa fragments collected from these patients and processed by paraffin embedding technique. To identify the cell populations present in the inflammatory processes, we used the CD20, CD8, CD3 and CD68 markers. In the studied cases, we found the presence of changes that have interested both the epithelium and lamina propria. Epithelium showed in particular epithelial hyperplasia aspects, with orthokeratinization and parakeratinization areas and, in some sections, areas of ulceration. We found the inflammatory process present in the lamina propria to be chronic and it consists in particular of lymphocytes, plasma cells and macrophages. This process was differentiated in intensity from one case to another, but varied even within the same case, from one area to another. Inflammation was determined by the local microbial flora enhanced by the action of prosthetic appliances or by the prolonged edentulous state. We observed more intense changes in denture wearers patients. The inflammatory response indicates the reactivity of the edentulous mucosa in response to local aggression, the specific defense mechanism coexisting with the nonspecific defense mechanism, with predominance of cellular immune defense.
PubMed: 25826498
Affiliations:
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Clinical and immunohistochemical study.</title><author><name sortKey="Cr I Oiu, Monica Mihaela" sort="Cr I Oiu, Monica Mihaela" uniqKey="Cr I Oiu M" first="Monica Mihaela" last="Cr I Oiu">Monica Mihaela Cr I Oiu</name><affiliation wicri:level="1"><nlm:affiliation>Department of Prosthetic Dentistry, Faculty of Dental Medicine, University of Medicine and Pharmacy of Craiova, Romania; mcraitoiu@yahoo.com.</nlm:affiliation><country wicri:rule="url">Oman</country><wicri:regionArea>Department of Prosthetic Dentistry, Faculty of Dental Medicine, University of Medicine and Pharmacy of Craiova</wicri:regionArea><wicri:noRegion>University of Medicine and Pharmacy of Craiova</wicri:noRegion></affiliation></author><author><name sortKey="M Rg Ritescu, Claudiu" sort="M Rg Ritescu, Claudiu" uniqKey="M Rg Ritescu C" first="Claudiu" last="M Rg Ritescu">Claudiu M Rg Ritescu</name></author><author><name sortKey="Florescu, Alma" sort="Florescu, Alma" uniqKey="Florescu A" first="Alma" last="Florescu">Alma Florescu</name></author><author><name sortKey="Pascu, Roxana" sort="Pascu, Roxana" uniqKey="Pascu R" first="Roxana" last="Pascu">Roxana Pascu</name></author><author><name sortKey="Pico, Alina Monica" sort="Pico, Alina Monica" uniqKey="Pico A" first="Alina Monica" last="Pico">Alina Monica Pico</name></author><author><name sortKey="Pico, Andrei" sort="Pico, Andrei" uniqKey="Pico A" first="Andrei" last="Pico">Andrei Pico</name></author><author><name sortKey="Sab U, Mariana" sort="Sab U, Mariana" uniqKey="Sab U M" first="Mariana" last="Sab U">Mariana Sab U</name></author><author><name sortKey="Nicolae, Vasile" sort="Nicolae, Vasile" uniqKey="Nicolae V" first="Vasile" last="Nicolae">Vasile Nicolae</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:25826498</idno><idno type="pmid">25826498</idno><idno type="wicri:Area/PubMed/Corpus">000605</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000605</idno><idno type="wicri:Area/PubMed/Curation">000605</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000605</idno><idno type="wicri:Area/PubMed/Checkpoint">000605</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000605</idno><idno type="wicri:Area/Ncbi/Merge">005A03</idno><idno type="wicri:Area/Ncbi/Curation">005A03</idno><idno type="wicri:Area/Ncbi/Checkpoint">005A03</idno><idno type="wicri:doubleKey">1220-0522:2015:Cr I Oiu M:cell:populations:involved</idno><idno type="wicri:Area/Main/Merge">001357</idno><idno type="wicri:Area/Main/Curation">001354</idno><idno type="wicri:Area/Main/Exploration">001354</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Cell populations involved in the processes of local mucosal defense in extended partially edentulous and completely edentulous patients. Clinical and immunohistochemical study.</title><author><name sortKey="Cr I Oiu, Monica Mihaela" sort="Cr I Oiu, Monica Mihaela" uniqKey="Cr I Oiu M" first="Monica Mihaela" last="Cr I Oiu">Monica Mihaela Cr I Oiu</name><affiliation wicri:level="1"><nlm:affiliation>Department of Prosthetic Dentistry, Faculty of Dental Medicine, University of Medicine and Pharmacy of Craiova, Romania; mcraitoiu@yahoo.com.</nlm:affiliation><country wicri:rule="url">Oman</country><wicri:regionArea>Department of Prosthetic Dentistry, Faculty of Dental Medicine, University of Medicine and Pharmacy of Craiova</wicri:regionArea><wicri:noRegion>University of Medicine and Pharmacy of Craiova</wicri:noRegion></affiliation></author><author><name sortKey="M Rg Ritescu, Claudiu" sort="M Rg Ritescu, Claudiu" uniqKey="M Rg Ritescu C" first="Claudiu" last="M Rg Ritescu">Claudiu M Rg Ritescu</name></author><author><name sortKey="Florescu, Alma" sort="Florescu, Alma" uniqKey="Florescu A" first="Alma" last="Florescu">Alma Florescu</name></author><author><name sortKey="Pascu, Roxana" sort="Pascu, Roxana" uniqKey="Pascu R" first="Roxana" last="Pascu">Roxana Pascu</name></author><author><name sortKey="Pico, Alina Monica" sort="Pico, Alina Monica" uniqKey="Pico A" first="Alina Monica" last="Pico">Alina Monica Pico</name></author><author><name sortKey="Pico, Andrei" sort="Pico, Andrei" uniqKey="Pico A" first="Andrei" last="Pico">Andrei Pico</name></author><author><name sortKey="Sab U, Mariana" sort="Sab U, Mariana" uniqKey="Sab U M" first="Mariana" last="Sab U">Mariana Sab U</name></author><author><name sortKey="Nicolae, Vasile" sort="Nicolae, Vasile" uniqKey="Nicolae V" first="Vasile" last="Nicolae">Vasile Nicolae</name></author></analytic><series><title level="j">Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie</title><idno type="ISSN">1220-0522</idno><imprint><date when="2015" 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bouche</term><term>Épithélium</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Bouche édentée</term><term>Muqueuse de la bouche</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Mouth Mucosa</term><term>Mouth, Edentulous</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Macrophages</term><term>Plasma Cells</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Antigènes CD</term><term>Antigènes CD20</term><term>Antigènes de différenciation des myélomonocytes</term><term>Macrophages</term><term>Plasmocytes</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Epithelium</term><term>Mouth Mucosa</term><term>Mouth, Edentulous</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Female</term><term>Gene Expression Regulation</term><term>Humans</term><term>Immunohistochemistry</term><term>Inflammation</term><term>Male</term><term>Middle Aged</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Femelle</term><term>Humains</term><term>Immunohistochimie</term><term>Inflammation</term><term>Mâle</term><term>Régulation de l'expression des gènes</term><term>Sujet âgé</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Considering the fact that extended partial edentation and complete edentation have high incidence rates worldwide, the necessity for correct prosthetic treatment is very important. We performed a clinical study on 37 extended partially edentulous patients and completely edentulous patients, who were divided into three groups. We also performed a morphological study using classic techniques of histology and immunohistochemistry methods on sections obtained from oral mucosa fragments collected from these patients and processed by paraffin embedding technique. To identify the cell populations present in the inflammatory processes, we used the CD20, CD8, CD3 and CD68 markers. In the studied cases, we found the presence of changes that have interested both the epithelium and lamina propria. Epithelium showed in particular epithelial hyperplasia aspects, with orthokeratinization and parakeratinization areas and, in some sections, areas of ulceration. We found the inflammatory process present in the lamina propria to be chronic and it consists in particular of lymphocytes, plasma cells and macrophages. This process was differentiated in intensity from one case to another, but varied even within the same case, from one area to another. Inflammation was determined by the local microbial flora enhanced by the action of prosthetic appliances or by the prolonged edentulous state. We observed more intense changes in denture wearers patients. The inflammatory response indicates the reactivity of the edentulous mucosa in response to local aggression, the specific defense mechanism coexisting with the nonspecific defense mechanism, with predominance of cellular immune defense.</div></front></TEI><affiliations><list><country><li>Oman</li></country></list><tree><noCountry><name sortKey="Florescu, Alma" sort="Florescu, Alma" uniqKey="Florescu A" first="Alma" last="Florescu">Alma Florescu</name><name sortKey="M Rg Ritescu, Claudiu" sort="M Rg Ritescu, Claudiu" uniqKey="M Rg Ritescu C" first="Claudiu" last="M Rg Ritescu">Claudiu M Rg Ritescu</name><name sortKey="Nicolae, Vasile" sort="Nicolae, Vasile" uniqKey="Nicolae V" first="Vasile" last="Nicolae">Vasile Nicolae</name><name sortKey="Pascu, Roxana" sort="Pascu, Roxana" uniqKey="Pascu R" first="Roxana" last="Pascu">Roxana Pascu</name><name sortKey="Pico, Alina Monica" sort="Pico, Alina Monica" uniqKey="Pico A" first="Alina Monica" last="Pico">Alina Monica Pico</name><name sortKey="Pico, Andrei" sort="Pico, Andrei" uniqKey="Pico A" first="Andrei" last="Pico">Andrei Pico</name><name sortKey="Sab U, Mariana" sort="Sab U, Mariana" uniqKey="Sab U M" first="Mariana" last="Sab U">Mariana Sab U</name></noCountry><country name="Oman"><noRegion><name sortKey="Cr I Oiu, Monica Mihaela" sort="Cr I Oiu, Monica Mihaela" uniqKey="Cr I Oiu M" first="Monica Mihaela" last="Cr I Oiu">Monica Mihaela Cr I Oiu</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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